In Silico Comparison Of The Effectiveness Of Assorted Drugs For Treating Swine Flu In Diverse Medical Systems

694 words - 3 pages

A global outbreak of a new strain of H1N1-2009 influenza virus, often referred to as “swine flu virus” is well-known for causing a huge number of deaths both in human and swine in recent years. The World Health Organization (WHO) reported about 15,174 deaths due to the pandemic influenza virus H1N1[1]. A pathogenic swine viral of H1N1 subtype has been proven to cause an outbreak of respiratory disease in both human and swine. Only during 1918-1919, influenza was first described as a disease of swine[2]. The first influenza virus was isolated from swine in 1930; the same was isolated from a human between 1974 and 2005[3]. H1N1 virus results when a previous triple fusion of bird, pig and human flu viruses further combines with a Eurasian pig flu virus[4]. While the virus is a major pathogen to humans, it does not disproportionately infect adults older than 60 years, which is an unusual and characteristic feature[5]. Similar to other influenza viruses, H1N1 is transmitted through respiratory droplets and not by eating pork or pork products. Similar to other influenza viruses, H1N1 also contains two surface antigens, namely hemagglutinin (HA) and neuraminidase (NA)[6]. The major role of HA involves in the viral entry mechanism and immune recognition through two subunits namely HA1 containing the receptor binding domain and HA2 responsible for the fusion of the virion with the endosomal membrane in the host cell[7]. Among the eight segments present in the genome of H1N1 virus, mutation is found to occur only at three segments. Maximum number of mutations occur at segments 1 and 4, coding for PB2 subunit of HA and comparatively less mutations occur at segment 6, coding for NA[8]. Among 144 combinatorial possibilities from 16 subtypes of HA and 9 subtypes of NA, only H1N1, H2N2 and H3N2 are human adapted viruses[9].
NA inhibitor antiviral drugs such as Oseltamivir (Tamiflu) and Zanamivir (Relenza) are widely used in allopathy to control this influenza virus[10]. Recent researches also report that Zanamivir is comparatively more effective in controlling the pathogenicity of this virus[10-11]. Yet both...

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