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Promethazine Essay

592 words - 3 pages

Laboratory Report # 3.2

        Promethazine 0.2% Syrup
Student Name:

        Describe the dispensing directions for the preparation:

        A. Indication and expected action:


        Promethazine HCL is a powerful antihistamine drug used to treat allergic conditions and,
        because of the sedative action, insomnia. It is also used as an anti-tussive in cough mixtures.
        Promethazine can be administered by mouth or injection.

        B. Directions/administration/use:

        TAKE ONE TEASPOONFUL OF SYRUP BY ...view middle of the document...

You should not use two doses at one time.

        Purpose of each excipient used in the experiment:

        flavoring agent
        sweetening agent, suspending and viscosity-increasing agent.
Liquid Glucose
        to provide calories, taste, and to improve transport of sodium
        and water across the intestinal barrier through osmosis
        used as a demulcent in cough preparations for soothing and protecting
        the mucous membranes and relieves irritation. When administered by
        mouth or parenterally, glycerin increases the plasma osmolality,
        resulting in the movement of water by osmosis from the extra vascular
        spaces into the plasma.
Sodium Chloride-
        electrolyte - source of sodium (Na+), used in combination with glucose for oral rehydration in acute diarrhea.
        flavoring/perfuming agent
Sodium Benzoate
        preservative with antibacterial and anti-fungal properties
Pure Water

        Show your calculations and compounding (in steps):


Promethazine HCL
        2 g
        (90mL / 1000mL)
        0.18 g
        180 g
        (90mL / 1000mL)

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